Prevalence of Beta-Cell, Thyroid and Celiac Autoimmunity in North Indian Children with Recent Onset Type 1 Diabetes (T1D)
Published: March 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.5711
Devi Dayal, Madhusudan Samprati, Navchetan Kaur, Ranjana Walker Minz, Dhaarani Jayaraman
1. Additional Professor, Pediatric Endocrinology & Diabetes Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
2. Registrar, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
3. Research Scholar, Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
4. Professor, Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
5. Registrar, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Correspondence
Dr. Devi Dayal,
Additional Professor, Pediatric Endocrinology & Diabetes Unit, Department of Pediatrics, Advanced Pediatrics Center,
Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.
E-mail: drdevidayal@gmail.com, dayal.devi@pgimer.edu.in
There is wide variation in the prevalence of pancreatic and other major autoantibodies in different patient populations of Type 1 diabetes (T1D) across continents and even within countries. The data on frequency of associated autoimmunity Indian children with T1D is limited. A retrospective record review of 310 children aged 7.28±3.3 y (range 0.7-15 y) with recently diagnosed T1D attending our Pediatric Diabetes Clinic between April 2004 to September 2014, showed positivity for anti-GAD65, anti-IA2b, anti-TPO and anti-tTGA of 50% (64/128), 16% (12/72), 18.7% (23/123) and 22% (47/212) respectively. The male:female ratio in patients with anti-GAD, anti-TPO and anti-tTG positivity was 1.3, 0.7 and 0.6 respectively. In conclusion, our patient cohort exhibited a moderate prevalence of anti-GAD 65, low prevalence of anti-TPO and high prevalence of anti-tTGA autoantibodies as compared to previous reports. Male preponderance was noted in children with GAD65 positivity.
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